Background:

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.

Applications:

ELISA, WB

Name of antibody:

ME2

Immunogen:

Synthetic peptide of human ME2

Full name:

malic enzyme 2

Synonyms:

ODS1

SwissProt:

P23368

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

65 kDa

WB Positive control:

Jurkat cell lysate

WB Recommended dilution:

500-2000